I'm not sure what the benefit of mixing them would be? Depending on where you get it, and in what quantities, the perlite is most likely more expensive. The coco coir/chips will hold moisture better than the perlite. But if you were not using the coco chips, and used the coco coir and wanted to add the perlite for a less dense and better aerated medium, that might be beneficial. But again that's why I like using the chips, they don't compact over time like the small particle regular coir can. Bottom line it wouldn't hurt anything to mix coco coir/chips with perlite, but it will most likely be more expensive.
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